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Abstract #4002

Long-Time-Scale Hyperpolarized Helium-3 Diffusion MRI: Global Versus Regional Measurements

Chengbo Wang1, John P. Mugler, III1, Eduard E. de Lange1, Talissa A. Altes1

1Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States

Global ADC values and regional ADC maps of hyperpolarized helium-3 in human lungs were measured at the long-time-scale in 19 healthy subjects and 19 smokers. For smokers, global ADC increased 107% (P<0.01) while mean of regional ADC maps increased 93% (P<0.01) compared with those of the controls. And global ADC strongly correlated with mean of regional ADC maps (r=0.96,P<0.001), suggesting global ADC may be a useful substitute for mean of regional ADC maps to investigate lung disease to save expensive 3He.