Abstract #4055

Assessment of AKI Severity in an Ischemia/reperfusion Mouse Model Using T2 Mapping: Comparison with Neutrophil Gelatinase Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM1)

Jan Hentschel¹, Lajos Marko², Erdmann Seeliger³, Dominik N. Mller²,⁴, Andreas Pohlmann¹, Thoralf Niendorf¹,²

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrck-Center for Molecular Medicine (MDC), Berlin, Germany; ²Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charit Medical Faculty and the Max-Delbrck-Center, Berlin, Germany; ³Institute for Vegetative Physiology, Charit Medical Faculty, Berlin, Germany; ⁴Department of Experimental Medicine I, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University, Erlangen-Nrnberg, Germany

Renal medullary hypoperfusion and hypoxia play a pivotal role in acute kidney injury (AKI). This study examines the correlation between MRI and NGAL/KIM1 in mouse AKI including ischemia/reperfusion injuries of different severity to elucidate the link between changes in T₂ and kidney physiology. The T₂ values derived from the medulla and cortex of clipped kidneys showed a strong correlation with NGAL. A similarly strong correlation was observed between KIM1 and T₂ deduced from the medulla. This indicates that T₂ -mapping may be useful as a non-invasive marker for the characterization of pathophysiological changes in mouse models of AKI.