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Abstract #4056

A Reinvestigation of the Feasibility and Reproducibility of Perfusion MRI in the Kidneys

Wen-Chau Wu1, 2, Mao-Yuan Su3, Chin-Cheng Chang3, Kao-Lang Liu3

1Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan; 2Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 3Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

Arterial spin labeling (ASL) and dynamic contrast enhanced (DCE) imaging are two established MRI techniques for quantitative perfusion measurement although their feasibility in the kidneys is still under investigation. One major challenge is glomerular filtration of the tracers used. Extended biophysical models have been proposed to account for dual outputs and/or inputs of tracers, which usually require additional scans and higher contrast-to-noise ratio (CNR). In this study, we assessed the feasibility and reproducibility of ASL and DCE in renal blood flow measurement using the original models and examined their CNR both in time and in space. Technical limitations were discussed.