Quantifying the Effects of Hyperoxia on Abdominal Tissue T1

Eleanor F. Cox¹, Emma L. Hall¹, Paula L. Croal¹, Ian D. Driver¹, Susan T. Francis¹

The longitudinal relaxation time (T1) of tissues has been suggested to be a potential biomarker for tissue oxygenation and previous studies have seen a reduction in T1 on breathing 100% oxygen. We induced hyperoxia in 5 subjects at 3T, and using a modified respiratory triggered IR-TrueFISP sequence and formed maps of the change in R1 in the renal cortex, spleen and liver during normoxia and hyperoxia. There was a reduction in R1 in the spleen and renal cortex, but no change in R1 in the liver on hyperoxia.