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Abstract #4057

Quantifying the Effects of Hyperoxia on Abdominal Tissue T1

MAGNA25Eleanor F. Cox1, Emma L. Hall1, Paula L. Croal1, Ian D. Driver1, Susan T. Francis1

1SPMMRC, School of Physics & Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

The longitudinal relaxation time (T1) of tissues has been suggested to be a potential biomarker for tissue oxygenation and previous studies have seen a reduction in T1 on breathing 100% oxygen. We induced hyperoxia in 5 subjects at 3T, and using a modified respiratory triggered IR-TrueFISP sequence and formed maps of the change in R1 in the renal cortex, spleen and liver during normoxia and hyperoxia. There was a reduction in R1 in the spleen and renal cortex, but no change in R1 in the liver on hyperoxia.