Histogram Analysis to Evaluate Changes on Parametric Maps: Preliminary Application to Renal BOLD MRI

Anindya Sen¹, Lu-Ping Li¹, Ujala Bokhary¹, Ioannis Koktzoglou¹, Pottumarthi V. Prasad¹

Parametric maps, e.g. T1, T2, ADC (apparent diffusion coefficient) etc. are routinely used to evaluate functional changes in tissue. Regions of interest (ROI) measurements are commonly employed to evaluate the observed changes which may not fully characterize the spatial variations in the measurements inherently present in images. In this preliminary study, we have evaluated a histogram based analysis of R2* maps for renal BOLD MRI. Using centroid to represent the histogram distribution, we show that the displacement in the geometric centroids obtained pre- and post-furosemide could be used as a parametric measure for change.