Quantitative Multi-Parametric MRI Evaluation of Kidneys in Subjects with CKD

Pottumarthi V. Prasad¹, Lu-Ping Li¹, Muhammad Haque¹, Anindya Sen¹, Ujala Bokhary¹, Heather Koenigs¹, Rajiv Agarwal², Stuart Sprague³

Chronic kidney disease (CKD) involves progressive reduction in renal function and is associated with increasing levels of fibrosis and reduction in renal volume. Additionally, it is becoming clear that hypoxia plays a key role both in the initiation and progression of CKD. Here, preliminary data of renal volume, ADC and BOLD MRI measurements obtained in patients with CKD and healthy controls are presented. It is evident that enhanced hypoxia is present even at mild to moderate levels of CKD and there was correlation between R2* and ADC values, consistent with the hypothesis that hypoxia stimulates fibrogenesis.