Abstract #4069

Imaging the PH Changes in a Glycerol-Induced Acute Kidney Injury Mouse Model with a MRI-CEST PH-Responsive Contrast Agent

Dario Livio Longo¹, Alice Busato¹, Stefania Lanzardo², Federica Antico³, Silvio Aime¹

¹Molecular Imaging Center, University of Torino, Torino, Italy; ²Department of Clinical and Biological Sciences, University of Torino, Torino, Italy; ³Department of Internal Medicine, University of Torino, Torino, Italy

pH is an important microenvironment parameter, in fact a number of disease states are associated with alterations in pH, such as ischemia, inflammation, infection and cancer, and many kidney injuries are associated with a perturbation of renal pH, therefore imaging techniques able to report in vivo on pH modifications would have a great relevance. The aim of the work was to investigate the use of Iopamidol as a MRI-CEST pH reporter of the disease evolution in glycerol-induced AKI model, exploiting the capability to image pH values in different regions for single kidneys.