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Abstract #4069

Imaging the PH Changes in a Glycerol-Induced Acute Kidney Injury Mouse Model with a MRI-CEST PH-Responsive Contrast Agent

Dario Livio Longo1, Alice Busato1, Stefania Lanzardo2, Federica Antico3, Silvio Aime1

1Molecular Imaging Center, University of Torino, Torino, Italy; 2Department of Clinical and Biological Sciences, University of Torino, Torino, Italy; 3Department of Internal Medicine, University of Torino, Torino, Italy

pH is an important microenvironment parameter, in fact a number of disease states are associated with alterations in pH, such as ischemia, inflammation, infection and cancer, and many kidney injuries are associated with a perturbation of renal pH, therefore imaging techniques able to report in vivo on pH modifications would have a great relevance. The aim of the work was to investigate the use of Iopamidol as a MRI-CEST pH reporter of the disease evolution in glycerol-induced AKI model, exploiting the capability to image pH values in different regions for single kidneys.