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Abstract #4115

Optimistaion of B-Value Distribution in Biexponential Modelling

Peter Gibbs1, Martin D. Pickles1, Lindsay W. Turnbull1

1University of Hull, Hull, East Yorkshire, United Kingdom

Bi-exponential fitting of DWI data to account for microperfusion effects is becoming increasingly prevalent both in the brain and other organs. Increased sampling of low b-values to adequately define the bi-exponential curve appears necessary. However, little work has attempted to assess the optimum b-value sampling strategy. Using synthetic data this study demonstrates that a highly non-linear sampling scheme is necessary for tissues with a rapid and large perfusive component and that high SNR data is required to appropriately define tissues with a small perfusive fraction.