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Abstract #4132

Pretreatment Diffusion-Weighted Imaging at 3T for Overall Survival Prediction in Chemoradiotherapy Treated Advanced Cervical Cancer Patients.

Martine I. Dujardin1, Martin D. Pickles1, Abdullah Aldosary2, Peter Gibbs1, Lindsay W. Turnbull1

1Centre for MR Investigations, University of Hull in association with Hull York Medical School, Hull, United Kingdom; 2King Fahad Medical City, Riyadh, Saudi Arabia

This study investigates the ability of pretreatment ADCs acquired at 3T to predict overall survival (OS) in chemoradiotherapy in advanced cervical cancer patients (N=26). The use of group median (p=0.16 ) or 75th percentile of group ADC values (p=0.86) as a dichotomizing value did not result in a significant difference for survival between a high and low ADC group. Kaplan-Meier analysis showed that the survival rate in the low-ADC group was significantly worse than that in the high-ADC value group (p=0.042) when groups were dichotomized on the basis of the 25th percentile (0.8510-3 mm2/s) of group pretreatment ADC values.