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Abstract #4195

CEST Imaging with Alternating-Offset-Saturation BSSFP

Qi Liu1, 2, Zhaoyang Fan2, Wafa Tawackoli2, Gadi Pelled2, Dan Gazit2, Yutaka Natsuaki3, Debiao Li2, 4

1Northwestern University, Chicago, IL, United States; 2Cedars-Sinai Medical Center, Los Angeles, CA, United States; 3Siemens Healthcare, Los Angeles, CA; 4University of California, Los Angeles, CA, United States

Balanced steady-state-free-precession (bSSFP) allows rapid imaging with high SNR efficiency. However, it is sensitive to scanner frequency drift, especially when long imaging time is required such as in CEST imaging. We developed an alternating-offset-saturation bSSFP (AOS-bSSFP) technique for more accurate CEST detection, as demonstrated by excellent agreement with TSE CEST in MTR asym plot both in phantom and in vivo scans.