Abstract #4195

CEST Imaging with Alternating-Offset-Saturation BSSFP

Qi Liu¹,², Zhaoyang Fan², Wafa Tawackoli², Gadi Pelled², Dan Gazit², Yutaka Natsuaki³, Debiao Li²,⁴

¹Northwestern University, Chicago, IL, United States; ²Cedars-Sinai Medical Center, Los Angeles, CA, United States; ³Siemens Healthcare, Los Angeles, CA; ⁴University of California, Los Angeles, CA, United States

Balanced steady-state-free-precession (bSSFP) allows rapid imaging with high SNR efficiency. However, it is sensitive to scanner frequency drift, especially when long imaging time is required such as in CEST imaging. We developed an alternating-offset-saturation bSSFP (AOS-bSSFP) technique for more accurate CEST detection, as demonstrated by excellent agreement with TSE CEST in MTR _asym plot both in phantom and in vivo scans.