Rescalable Spillover Prediction for Optimization of Pulsed Magnetization Transfer and CEST Experiments

Moritz Zaiss¹, Peter Bachert¹

A rescaling property for simulated direct water saturation maps for pulsed RF irradiation at different frequency offsets is introduced. It allows prediction of regions of low spillover effect for a specific pulse train for all offsets of interests by simply rescaling one simulated spillover map. Additionally, for each simulated pulse power and duration the same map shows to provide the whole symmetric z-spectrum. This makes the search of low spillover regions quick and easy which is interesting for optimization of pulsed magnetization transfer and CEST experiments where small chemical shifts relative to the water protons lead to strong signal dilution by spillover effect.