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Abstract #4258

Optimization of Saturation Pulse Length in Parallel Transmission Based Amide Proton Transfer MRI for Oncology Applications

Jochen Keupp1, Osamu Togao2, Jinyuan Zhou3, Yuriko Suzuki4, Takashi Yoshiura2

1Philips Research, Hamburg, Germany; 2Department of Clinical Radiology, Kyushu University, Fukuoka, Japan; 3Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 4Philips Electronics Japan, Tokyo, Japan

Amide proton transfer (APT) offers a novel route to sensitive MR molecular imaging of endogenous cytosolic proteins and is expected to play an important role in delineation/classification of active tumor tissue for therapy planning/monitoring. The length of RF saturation (Tsat) is a key for sensitivity, in particular at low protein concentrations. With novel parallel transmission based techniques, Tsat>1s is possible on clinical scanners. A thorough protocol optimization is needed for tumor contrast and contrast-to-noise ratio. In a phantom study and acquiring first exemplary clinical brain tumor data, the effect of Tsat on the APT contrast is studied in the range of Tsat=0.5s up to 4s.