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Abstract #4259

An Automatic Real-Time Optimization of MT Off-Resonance Frequency

Jyun-Ming Tsai1, Teng-Yi Huang1, Hsu-Hsia Peng2, Yi-Chun Wu3, Fu-Nien Wang2

1Electrical Engineering, National Taiwan University of Science and Technology, Tapei, Taiwan; 2Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 3Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan

This study presents an automatically real-time feedback optimization for frequency adjustment of magnetization transfer imaging. We proposed a general framework that can automatically optimize MT frequency based on the obtain image. The optimization can account for a whole field-of-view or a specific region-of-interest (ROI). We demonstrate this system by an experiment calibrating the central frequency of MT pulse for a ROI. The system was tested on a rabbit leg muscle. The frequency obtained by the real-time system was consistent with that obtained by a long sweep frequency scan. We therefore concludes the proposed system is a potential useful tool for MT-related studies, such as APT imaging.