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Abstract #4267

Rapid and Accurate Variable Flip Angle T1 Mapping with Correction of On-Resonance MT Effects

Pouria Mossahebi1, Alexey A. Samsonov2

1Biomedical Engineering, University of Wisconsin, Madison, WI, United States; 2Radiology, University of Wisconsin Madison, Madison, WI, United States

Accurate estimation of T1 values from VFA measurements requires consideration of magnetization transfer effects, which may introduce T1 bias roughly proportional to the macromolecular content. The fast T1 correction protocol developed in this work (VFA-MT) requires a single MT scan in addition to regular VFA measurements for accurate T1 mapping. The presented approach is promising for fast high-resolution whole brain T1 mapping within clinically acceptable scan times.