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Abstract #4268

Chemical Exchange Saturation Transfer (CEST) Imaging Using Interleaved Balanced Steady State Free Precession (SSFP)

Zhongliang Zu1, 2, Ke Li1, 2, Richard Dortch1, 2, Seth Smith1, 2, Mark D. Does1, 2, John Gore1, 2, Daniel Gochberg1,<s

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Department of Radiology, Vanderbilt University, Nashville, TN, United States

Conventional CEST sequences contain a long saturation block (several seconds of continuous wave or pulsed irradiation) before acquisition. To fill k-space, several saturation blocks followed by acquisitions may be required, especially in high-resolution imaging. The long scan time limits CEST imaging in clinical applications. Here we present a new CEST imaging method using interleaved balanced steady state free precession (SSFP) acquisitions (named SSFP-CEST) to shorten imaging time. Experiments on creatine/agar phantom show that the SSFP-CEST has similar contrast as that of pulsed-CEST, but the total acquisition time decreases by a factor of ~6.