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Abstract #4270

A 7min Protocol for Quantitative, Whole-Brain, Accurate Water Mapping at 3T for Neurological Applications

Ana-Maria Oros-Peusquens1, Fabian Keil1, Zaheer Abbas1, Vincent Gras1, Klaus H.M. Mllenhoff1, 2, N. Jon Shah1, 3

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Jlich, Jlich, Germany; 2Department of Cognitive Neuroscience, University Maastricht, Maastricht, Netherlands; 3JARA - Faculty of Medicine, RWTH Aachen University, Aachen, Germany

The method proposed here is based on a long-TR multiple-echo GRE measurement with 7:21 minutes acquisition time. It has the advantage that all B1 corrections, which are large, are multiplicative and can be approached heuristically, using a bias field correction. A simple exponential fit of the signal decay with echo time is the other postprocessing ingredient. Well-separated distributions are found for the WM and GM and agree very well with previous ones obtained at 1.5T. It is anticipated that this easy to use, high-quality water mapping method will open the road to routine, widespread quantitative MR imaging of water content.