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Abstract #4301

On the Use of 13-C Labelled Anhydrides as Chemical Precursors of Short Chain Fatty Acids for DNP-MRS.

Fabio Tedoldi1, Sonia Colombo Serra1, 2, Magnus Karlsson3, Giovanni Battista Giovenzana4, 5, Camilla Cavallotti5, Fulvio Uggeri1, Silvio Aime6

1Centro Ricerche Bracco, Bracco Imaging Spa, Colleretto Giacosa, Torino, Italy; 2Dipartimento di Fisica Sperimentale, Universit degli Studi di Torino, Torino, Italy; 3Albeda Research, Copenhagen, Denmark; 4Dipartimento di Scienze Chimiche Alimentari Farmaceutiche e Farmacologiche, Universit degli Studi del Piemonte Orientale, Novara, Italy; 5CAGE Chemicals srl, Novara, Italy; 6Dipartimento di Chimica IFM, Universit degli Studi di Torino, Torino, Italy

Hyperpolarized 13-C labelled butyric and acetic acids are potentially valuable tracers for investigating cardiac metabolism. Unfortunately they can not be polarized as neat compounds, but only after addition of a glass forming agents which could affect their metabolic fate. Symmetric anhydrides are here proposed as chemical precursors, which can be polarized as such and provide, upon dissolution and hydrolysis, a highly concentrated neat solution of the corresponding acid. In addition, tailored lipophilic derivatives of trityl radicals have been investigated and shown to be suitable polarization agents for anhydrides, that can be easily removed by filtration upon dissolution in aqueous media.