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Abstract #4302

Multi-Side Kinetic Modeling of 13C Metabolic MR Using [1-13C]pyruvate

Pedro A. Gmez Damian1, 2, Jonathan I. Sperl1, Oleksandr Khegai1, Stefan Grott1, Eliane Weidl3, Martin A. Janich3, Florian Wiesinger1, Steffen J. Glaser4, Ax

1GE Global Research, Munich, Germany; 2Tecnologico de Monterrey, Monterrey, Mexico; 3Nuclear Medicine, Technische Universitt Mnchen, Munich, Germany; 4Department Chemie, Technische Universitt Mnchen, Munich, Germany; 5IMETUM, Technische Universitt Mnchen, Munich, Germany

Quantitation of metabolite conversion through a multi-side kinetic model that involves all downstream metabolites present in MR spectroscopy after injection of [1-13C]pyruvate is presented. This method provides more kinetic data than previously existing methods and parameter interdependency allows a more accurate quantitation that can be useful for the monitoring of metabolic activity. The results are compared to kinetic modeling obtained with two-side integral and two-side differential models.