Maxim Terekhov1, Jan Krummenacker1, 2, Vasyl Denisenkov3, Kathrin Gerz1, Thomas Prisner3, Laura Maria Schreiber1
1Section of Medical Physics, Radiology Department, University Medical Center Mainz, Mainz, Germany; 2Institute of Physical and Theoretical Chemistry , Center for Bimolecular Magnetic Resonance Goethe-University, Frankfurt-am-Main, Germany; 3Institute of Physical and Theoretical Chemistry, Center for Bimolecular Magnetic Resonance Goethe-University, Frankfurt-am-Main, Germany
Dynamic Nuclear Polarization (DNP) is a technique, in which hyperpolarization is achieved by microwave irradiation of electron spins in radicals. The NMR signal enhancement by factor 600 is potentially possible. Typically DNP is achieved in external polarizers at low temperatures. Being optimal for signal enhancements; the requirement to shuttle prohibits the use nuclei with short T1, e.g. 1H. To circumvent these we implemented liquid-state DNP at 1.5T for 1H that allows polarization inside MRI bore close to the imaging objects and continuous-flow delivery of hyperpolarized agent. The fluid micro-jets visualization with resolution of 100 m was achieved in pilot experiments.