Abstract #4312

Metabolic Response of Glioma to Dichloroacetate Measured by Hyperpolarized 13C MRSI

Jae Mo Park¹,², Lawrence Recht³, Sonal Josan²,⁴, Taichang Jang³, Milton Merchant³, Yi-Fen Yen⁵, Ralph E. Hurd⁵, Daniel M. Spielman,¹²,

¹Electrical Engineering, Stanford University, Stanford, CA - California, United States; ²Radiology, Stanford University, Stanford, CA - California, United States; ³Neurology and Neurological Sciences, Stanford University, Stanford, CA - California, United States; ⁴Neuroscience Program, SRI International, Menlo Park, CA - California, United States; ⁵Applied Science Laboratory, GE Healthcare, Menlo Park, CA - California, United States

We demonstrate that measuring 13C-Bic is feasible to assess PDH flux and effect of DCA in tumor-bearing rat brain by injecting hyperpolarized [1-13C]Pyr. Lac/Bic gave a better contrast between glioma and normal brain, and reflected both pathways to cytoplasmic and mitochondrial metabolism.