Abstract #4316

Evaluating Tumor Perfusion with Hyperpolarized HP001 and Comparison with Dynamic Susceptibility Contrast MR Imaging and Pathology Using Orthotopic Human GBM Xenografts

Ilwoo Park¹, Cornelius von Morze¹, Jan H. Ardenkjaer-Larsen², Janine M. Lupo¹, Motokazu Ito³, Joydeep Mukherjee³, Joanna J. Phillips³, Russell O. Pieper³, Daniel B. Vi

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; ²GE Healthcare, Broendby, Denmark; ³Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States; ⁴Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States

We have demonstrated the feasibility of using hyperpolarized HP001 for investigating tumor perfusion in an orthotopic human GBM model. Distinct HP001 characteristics were found between tumor and normal tissues. HP001 data were strongly correlated with the data from the conventional Gd-based DSC imaging and consistent with the findings from immunohistochemical analysis. The results of this study suggest that this technique may provide an alternate way to evaluate tumor perfusion for brain tumors, which could be applied in patient studies.