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Abstract #4318

Comparison of Localized Hyperpolarized 13C-Pyruvate and 13C-Urea Dynamics in Tumor Models

Peder E. Z. Larson1, Kayvan R. Keshari, David M. Wilson, Simon Hu, Michael Lustig2, Adam B. Kerr3, John M. Pauly3, John Kurhanewicz, Daniel B. Vigneron

1UCSF, San Francisco, CA, United States; 2UC Berkeley; 3Stanford University

Copolarization followed by simultaneous injection of [1-13C]-pyruvate (metabolic marker) and 13C-urea (perfusion marker) was combined with a dynamic 3D EPSI acquisition using multiband excitation pulses and compressed sensing to better characterize perfusion and uptake of hyperpolarized agents. Using urea as a separate perfusion marker allowed for improved distinction between perfusion of metabolic products (ie [1-13C]-lactate) and tissue metabolic conversion.