Abstract #4319

Detecting Early Tumor Response of Prostate Cancer to Radiation Therapy Using Multi-Parametric 14T 1H and Hyperpolarized 13C MR Imaging

Vickie Zhang¹,², Robert Bok¹, Subramaniam Sukumar¹, Adam Cunha³, I-C. Hsu³, Jean Pouliot,²³, Daniel B. Vigneron¹,², John Kurhanewicz¹,

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; ²Graduate Program in Bioengineering, University of California, San Francisco - University of California, Berkeley, Berkeley, CA, United States; ³Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, United States

This study used multi-parametric ¹H and hyperpolarized ¹³C MR imaging in the TRAMP model to investigate early response in perfusion, diffusion and metabolism to the impact of increasing dose levels of radiation therapy. TRAMP mouse were treated with a radiation dose distribution from 14Gy to 5Gy within the tumor. Both ¹H (t₂-weighted, DCE and DWI) and hyperpolarized ¹³C ([1-¹³C] pyruvate and ¹³C urea) imaging was done before treatment and serially after treatment. HP ¹³C biomarkers correlated with conventional ¹H MR markers. Significant dose dependent changes in perfusion and pyruvate-to-lactate flux were observed following radiation therapy.