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Abstract #4320

Regulating Myocardial Metabolism by Infusion of Glucose, Insulin and Potassium in Hyperpolarized [1-13C]Pyruvate MRS Studies

Mette Hauge Lauritzen1, Peter Magnusson1, Sadia Asghar Butt1, Lise Vejby Sgaard1, Jan Henrik Ardenkjr-Larsen2, Per keson1

1Danish Research Centre for Magnetic Resonance (DRCMR) Copenhagen University Hospital, Hvidovre, Denmark; 2GE Healthcare, Hillerd, Denmark

Changes in myocardial metabolism play an important role in the etiology of different cardiac diseases. MR Spectroscopy with hyperpolarized [1-13C]pyruvate can visualize myocardial metabolism. However, the usability of the technique can be complicated, because it depends on high myocardial glucose availability, which can be difficult to control during in vivo MR studies. This study demonstrate how infusion of glucose, insulin and potassium can increase the [13C]bicarbonate MRS-signal significantly after injection of hyperpolarized [1-13C]pyruvate in rats. This improves the sensitivity of the technique to assess metabolic changes in the myocardium as a result of disease.