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Abstract #4360

Improved Identification of Ferritin-Tagged Grafts in Mouse Heart at Higher Magnetic Field Strength

Anna V. Naumova1, 2, Vasily L. Yarnykh1, 2, Niranjan Balu1, 2, Hans Reinecke, 23, Charles E. Murry, 23, Chun Yuan1, 2

1Radiology, University of Washington, Seattle, WA, United States; 2Center for Cardiovascular Biology, University of Washington, Seattle, WA, United States; 3Pathology, University of Washington, Seattle, WA, United States


Mouse skeletal myoblasts were genetically modified to overexpress ferritin, a natural iron storage protein. T2 relaxivity of ferritin-tagged cells dramatically increased with increase of the magnetic field strength; thus improves MRI graft identification and assessment of the graft size.

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