Abstract #4359

Rescue of LV Dysfunction in a Pig Ischemia-Reperfusion Injury Model by Human Amnion-Derived Mesenchymal Stem Cells Tracked by Manganese-Enhanced MRI

Rajesh Dash¹, Ildiko Toma¹, Fumiaki Ikeno¹, Jennifer K. Lyons¹, Shahriar Heidary¹, Marie-Claude Parent¹, I-Ning E. Wang¹, Xiaohu Ge¹, Justin Lam¹, Jaehoon C

¹Cardiovascular Medicine, Stanford University Medical Center, STANFORD, CA- CALIFORNIA, United States; ²Medicine / Cardiology, University of Illinois-Chicago, Chicago, IL, United States; ³Cardiac Surgery, Stanford University Medical Center; ⁴Electrical Engineering, Stanford University; ⁵Eagle Vision Pharmaceutical Corporation, Downington, PA, United States

Human Amnion-derived Mesenchymal Stem Cells (hAMSCs) were transplanted into the infarct and peri-infarct regions of a pig ischemia-reperfusion model. The hAMSC therapy improved cardiac systolic function post-MI, compared to control animals, and Cardiac MRI with Manganese-Enhanced MRI (MEMRI) was able to detect increased CNR from live populations of hAMSCs within infarct and peri-infarct zones, as confirmed by human nuclear antigen (hNA) immunostaining.