Rajesh Dash1, Justin Lam1, Ildiko Toma1, Yongquan Gong2, Robert C. Robbins2, Paul C. Simpson3, 4, Phillip C. Yang1
1Cardiovascular Medicine, Stanford University Medical Center, San Francisco, CA, United States; 2Cardiac Surgery, Stanford University Medical Center; 3Medicine / Cardiology, UCSF Medical Center, San Francisco, CA, United States; 4Cardiology, San Francisco VA Medical Center, San Francisco, CA, United States
A novel anti-apoptotic alpha-adrenergic agonist preserves left ventricular ejection fraction in mice following myocardial infarction. This therapeutic effect is able to be detected and quantified non-invasively, using T2* signal loss assessment of an Annexin-SPIO molecular apoptosis probe.