Abstract #4358

Molecular MRI-Based Detection of an Alpha-1A Receptor Agonist Treatment for Ischemia-Induced Cardiac Apoptosis

Rajesh Dash¹, Justin Lam¹, Ildiko Toma¹, Yongquan Gong², Robert C. Robbins², Paul C. Simpson³,⁴, Phillip C. Yang¹

¹Cardiovascular Medicine, Stanford University Medical Center, San Francisco, CA, United States; ²Cardiac Surgery, Stanford University Medical Center; ³Medicine / Cardiology, UCSF Medical Center, San Francisco, CA, United States; ⁴Cardiology, San Francisco VA Medical Center, San Francisco, CA, United States

A novel anti-apoptotic alpha-adrenergic agonist preserves left ventricular ejection fraction in mice following myocardial infarction. This therapeutic effect is able to be detected and quantified non-invasively, using T2* signal loss assessment of an Annexin-SPIO molecular apoptosis probe.