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Abstract #4366

Monitoring of Iron-PLLA Loaded MSCs After Silicone Carrier Application @ 11.7T

Ina Vernikouskaya1, 2, Natalie Fekete3, Alexander Erle3, Hubert Schrezenmeier3, Volker Rasche1, 2

1Internal Medicine II, University Hospital of Ulm, Ulm, Baden-Wuerttemberg, Germany; 2Small Animal MRI, University of Ulm, Ulm, Baden-Wuerttemberg, Germany; 3Institute of Clinical Transfusion Medicine and Immunogenetics, University Hospital of Ulm, Ulm, Baden-Wuerttemberg, Germany

The objective of this study was to use chemically defined silicone carrier as an delivery aid of the iPLLA-labeled MSCs to the skin wounds for further monitoring of the cell trafficking using MRI. The magnetic properties of iPLLA nanoparticles were investigated at 3T and at 11.7T. In Vitro imaging of a silicone carrier with attached labeled MSCs allowed to determine the amount of cells which could be good visualize and still remains attached to the carrier. in vivo imaging showed the attraction of the labeled MSCs to the skin wound and demonstrated that silicone carriers could be used as a vehicle for the application of MSCs to surface wounds.