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Abstract #4369

Mass Spectrometry Detection of Loss of Structural Integrity of Gd-DTPA Entrapped in J774 Machrophages

Eliana Gianolio1, Enza Di Gregorio1, Rachele Stefania1, Silvio Aime1

1Chemistry IFM & Molecular Imaging Center, University of Torino, Torino, Italy, Italy

Herein we report a mass spectrometric method for accurate detection and quantification of a Gd-complex after its internalization in living cells. This method allowed to determine if, and how Gd-complexes endowed with different thermodynamic stability can be transformed once entrapped into living cells.