Abstract #4369

Mass Spectrometry Detection of Loss of Structural Integrity of Gd-DTPA Entrapped in J774 Machrophages

Eliana Gianolio¹, Enza Di Gregorio¹, Rachele Stefania¹, Silvio Aime¹

¹Chemistry IFM & Molecular Imaging Center, University of Torino, Torino, Italy, Italy

Herein we report a mass spectrometric method for accurate detection and quantification of a Gd-complex after its internalization in living cells. This method allowed to determine if, and how Gd-complexes endowed with different thermodynamic stability can be transformed once entrapped into living cells.