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Abstract #4399

The Influence of Template Metabolite Omissions on 1H-MRS Quantification

Reggie Taylor1, 2, Peter Williamson, 13, Jean Thberge, 12

1Medical Biophysics, University of Western Ontario, London, ON, Canada; 2Medical Imaging, Lawson Health Research Institute, London, ON, Canada; 3Psychiatry, University of Western Ontario, London, ON, Canada

Many metabolites contribute to the area in a 1H-MRS spectrum, but not all are accounted for in every basis set. If they are not included in the basis set, their area may likely lead to an error in another metabolites concentration estimate. The purpose of this study was to systematically identify which metabolites compensate for a metabolites area when it has been omitted from a fitting template using Monte Carlo simulations. Every metabolite studied, with the exception of lactate, lead to an error of at least 10% in another metabolites concentration estimate when it was omitted from the template.