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Abstract #4400

Combination of Multichannel Single-Voxel MRS Data Using Generalized Least Squares

Li An1, Jan Willem van der Veen1, David M. Thomasson2, Jun Shen1

1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States; 2National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States

In recent years, various methods have been proposed for combining multichannel single-voxel MRS data. We propose to use a generalized least square (GLS) method to combine multichannel single-voxel MRS data. The proposed method was compared with two recently reported methods using data collected from two normal volunteers with an 8-channel receiver coil and data collected from a phantom with a 32-channal receiver coil. The experimental results show that the GLS method has the lowest coefficient of variation compared to the two existing methods, which will lead to improved precision in metabolite quantification in multi-measurement MRS studies.