Abstract #4413

Assessment of Lactate in LDH-A Silenced 4T1 Tumors with Selective Multiple-Quantum Coherence Transfer

Asif Rizwan¹,², Inna Serganova³, Xiaohui Ni¹, Sunitha Thakur¹,⁴, Kristen Zakian¹,⁴, Ronald Blasberg³,⁴, Jason Koutcher¹,⁴

¹Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; ²Physiology and Biophysics, Weill Cornell Medical College, New York, NY, United States; ³Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; ⁴Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

Metabolic changes in primary tumors can lead to the development of the metastatic phenotype. The objective of this study is to demonstrate the link between LDH-A expression and lactate level in tumors. The LDH-A silenced 4T1 tumors have slower growth rate compare to the control 4T1 tumors. Both nonlocalized- and localized-spectra are acquired using the selective multiple-quantum coherence transfer (SelMQC) sequence in vivo. The LDH-A silenced 4T1 tumors showed a lower level of lactate compare to 4T1 control tumors.