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Abstract #4424

Dynamic 31P-MRS During Visual Stimulation Protocols in Healthy Young Adult Subjects

Felipe Rodrigues Barreto1, 2, Carlos Garrido Salmon1, 2, Thiago Bulhes3, 4, Ricardo Landim3, 4, Gabriela Castellano3, 4

1Department of Physics, University of So Paulo, FFCLRP, Ribeirao Preto, SP, Brazil; 2CInAPCe (Cooperao Interinstitucional de Apoio a Pesquisas sobre o Crebro), Ribeirao Preto, SP, Brazil; 3Neurophysics Group, UNICAMP, Institute of Physics Gleb Wataghin, Campinas, SP, Brazil; 4CInAPCe (Cooperao Interinstitucional de Apoio a Pesquisas sobre o Crebro), Campinas, SP, Brazil

31P-MRS combined with visual stimulation has been widely used to investigate energy metabolism in healthy subjects and patients. In this work we used a large number of subjects to assess metabolic variability in resting conditions and metabolic changes resulting from two visual stimulation protocols (short and long). Both protocols showed significant differences among on and off states for Pi (higher in on blocks) and for the PCr/Pi ratio (lower in on blocks), with a mean relative change of 13.4% (Pi, p=0.04) and -17.4% (PCr/Pi, p=0.007) for the short protocol and 5.3% (Pi,p=0.009) and -5.9% (PCr/Pi, p<0.001) for the long protocol.