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Abstract #4477

A Proton NMR Study of Serum and Urine in Pre and Post Nutritional Intervention in Buergers Disease

Abhinav Arun Sonkar1, shatakshi srivastava2, omprakash prajapati1, jitendra kumar kushwaha1, awanish kumar1, raja roy2

1Surgery, CSM Medical University, Lucknow, Uttar pradesh, India; 2center of biomedical magnetic resonance, SGPGI, Lucknow, Uttar pradesh, India

Proton NMR spectroscopic studies of serum of patients of Beurgers disease with simultaneous urine analysis have been performed. The detailed metabolic profile in serum demonstrated significant alterations in fatty acid metabolism and homocysteine metabolism of 16 patients suffering from Beurgers Disease. The post-nutritional intervention follow up of patients (n=5) was also investigated. Whereas, fatty acid and homocysteine metabolism showed significant alterations in serum samples of diseased patients, urinalysis did not indicate disease related variations. The post-nutritional follow up of patients showed substantial clinical improvement which correlated well with Nitric Oxide levels and NMR metabolic profile of the serum.