Yuan-Cheng Wang1, Shenghong Ju1, Gao-Jun Teng1
1Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, China
Arguments on the nephrotoxicity of iodixanol (iso-osmolality) and iopromide (low-osmolality) have not stopped so far. We performed a study to evaluate the diffusion and oxygenation of the two kinds of contrast medias using diffusion-weighted MR imaging (DWI) and blood oxygen level dependent (BOLD) MRI. The results indicate that iodixanol resulted in a more significant decrease of renal diffusion and oxygenation than iopromide did in the setting of mild dehydration on rabbits. This suggests that iodixanol may not be as safe as people used to think and further study is still needed.