Abstract #0028

Assessment of Experimental Acute Kidney Injury by Fast Interleaved Monitoring of T2* and T2

Andreas Pohlmann¹, Jan Hentschel¹, Mandy Fechner², Uwe Hoff², Gordana Bubalo², Karen Arakelyan¹,³, Kathleen Cantow³, Erdmann Seeliger³, Bert Flemming³, Lajos Marko⁴, Helmar Waiczies¹,⁵, Sonia Waiczies¹,⁵, Wolf Hagen Schunck⁴, Dominik N. Mueller⁴,⁶, Duska Dragun², Thoralf Niendorf¹,⁵

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany; ²Nephrology and Intensive Care Medicine, Center for Cardiovascular Research, Charit, Berlin, Germany; ³Institute of Physiology, Center for Cardiovascular Research, Charit, Berlin, Germany; ⁴Max Delbrck Center for Molecular Medicine, Berlin, Germany; ⁵Experimental and Clinical Research Center, a cooperation between the Charit Medical Faculty and the Max Delbrck Center for Molecular Medicine, Berlin, Germany; ⁶Nikolaus-Fiebiger-Center, Friedrich-Alexander-University, Erlangen-Nrnberg, Germany

Acute kidney injury (AKI) is commonly caused by renal hypoperfusion. This ischemia/reperfusion (I/R) injury is characterized by a mismatch of local tissue oxygen supply and demand. There is an unmet need to better understand the mechanisms of the initial phase of I/R injury in AKI. Mapping of T2*/T2, known to be sensitive to blood oxygenation, might elucidate spatio-temporal pathophysiological changes in the kidney. We demonstrate for the first time the feasibility of continuous, high temporal resolution parametric MRI monitoring of renal I/R in rats. Observations in the early reperfusion phase promise to offer new insights into the pathogenesis of AKI.