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Abstract #0091

MRI-US Fused Targeted Prostate Biopsy Detects Clinically Significant Cancer in Active Surveillance Patients Better Than 12 Core Random Biopsy with Less Than 4 Cores

Michael Da Rosa1, 2, Laurent Milot1, 3, Linda Sugar, 34, Danny Vesprini, 35, Hans Chung, 35, Andrew Loblaw, 35, Laurence Klotz, 36, Masoom A. Haider1, 3

1Department of Medical Imaging, University of Toronto, Toronto, ON, Canada; 2Institute of Medical Science, University of Toronto, Toronto, ON, Canada; 3Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 4Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; 5Radiation Oncology, University of Toronto, Toronto, ON, Canada; 6Division of Urology, University of Toronto, Toronto, ON, Canada


The purpose of this prospective study was to determine the ability of an MRI-US fusion biopsy system to detect clinically significant (CS) disease in active surveillance (AS) patients compared to random transrectal ultrasound (R-TRUS) guided biopsy (bx). Multiparametric MRI prospectively identified up to 4 suspicious targets in each patient. Biopsy was performed using an MRI-ultrasound navigation system (UroNav, Philips Healthcare). MRI-US fusion biopsy detected more CS cancers with fewer biopsy cores than random biopsy in AS patients. In addition, MRI in AS patients has a high negative predictive value for the presence of CS disease on subsequent biopsy.