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Abstract #0097

1H MRSI of Prostate Cancer Incorporating Spermine in the Quantification, a 7 Tesla Patient Study

Mariska P. Luttje1, Robin A. de Graaf2, Catalina S. Arteaga de Castro1, Peter R. Luijten1, Marco van Vulpen1, Uulke A. van der Heide3, Dennis W.J. Klomp1

1Imaging Division, Univerity Medical Center, Utrecht, Netherlands; 2MRRC, Yale University, New Haven, CT, United States; 3Department of Radiotherapy, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands

In this study at 7T, we show the influence of polyamines in the variability of the cho+pa+cr/cit vs cho+cr/cit ratio by using spectral fitting with simulated basissets at 7T instead of the commonly used signal integration when including more than 200 MR spectra obtained from six patients diagnosed with prostate cancer. Ratios excluding the fitted polyamines resonances show a clear trend towards less spread over the voxels (tumor as well as healthy).