Abstract #0098

Stratification of Disease Aggressiveness of Prostate Cancer Using MRSI and DWI

Durgesh Kumar Dwivedi¹, Girdhar Bora², Rajeev Kumar², Sanjay Thulkar³, Sanjay Sharma³, Siddhartha D. Gupta⁴, Naranamangalam R. Jagannathan¹

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; ²Department of Urology, All India Institute of Medical Sciences, New Delhi, Delhi, India; ³Department of Radio-diagnosis, All India Institute of Medical Sciences, New Delhi, Delhi, India; ⁴Department of Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India

The challenge to clinicians in the management of prostate cancer (PCa) patients is the in vivo assessment of disease aggressiveness. TRUS biopsy detects the PCa and determines the Gleason score. Identification of patients with more-aggressive disease would help to prevent overtreatment of those with low-risk tumors. Our results showed the reduction of metabolite ratios [Cit/(Cho+Cr)] and ADC values with the increase of Gleason score. The present study indicates that MRSI and DWI could stratify the PCa disease aggressiveness non-invasively.