Ke Zhang1, Hans Herzog1, Christian Filss1, Thomas Fischer2, Walter Sturm3, Burkhard Brocke2, Nadim Jon Shah1, 4
1Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Jlich GmbH, Jlich, Germany; 2Neurobiology of Personality and Neurogenetics, Department of Psychology, Dresden Universi Laboratory, Dresden, Germany; 3Clinical Neurology , University Hospital Aachen, Aachen, Germany; 4Department of Neurology, JARA, RWTH Aachen University, Aachen , Germany
A number of studies have compared ASL-MRI and 15O-water PET for the evaluation of ASL reliability and reproducibility. But none of these studies had the possibility to perform both techniques simultaneously to minimize the physiological variations. In this work, a simultaneous ASL-MRI and 15O-water PET approach has been implemented on a hybrid MR-PET for a truly quantitative comparison between the two methods in absolutely the same physiological and functional status.