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Abstract #0142

Can We Assess Cortical Bone Microstructure with Magnetic Resonance Imaging?

Won C. Bae1, Reni Biswas1, Shantanu Patil2, Christine Chung1, Darryl D. D'Lima2, Graeme M. Bydder3, Jiang Du1

1Radiology, University of California, San Diego, San Diego, CA, United States; 2Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, CA, United States; 3Radiology, University of California San Diego, San Diego, CA, United States

Bone water occurs at various locations and in different binding states, including water bound to organic matrix and free water residing in the microscopic pores of cortical bone. Cortical bone is typically regarded as MR invisible with conventional clinical MR sequences. In this study, we aimed to investigate bone water imaging with UTE and clinical FSE sequences, and to correlate the structure seen with FSE imaging with that seen with uCT imaging.