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Abstract #0144

Assessment of Bone Marrow Fat Fraction in the Presence of Trabecular Bone: Initial Comparison of Water-Fat Imaging with Single-Voxel MRS

Dimitrios C. Karampinos1, 2, Gerd Melkus1, Thomas Baum2, Jan S. Bauer2, Ernst J. Rummeny2, Roland Krug1

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany

Single-voxel MR spectroscopy has been the technique of choice for measuring fat content in localized bone marrow regions. However, there is a growing interest on applying quantitative water-fat imaging techniques to measure bone marrow fat content with high spatial resolution. Bone marrow fat content measurements in the presence of trabecular bone are hindered by strong susceptibility effects and short T2*. The present study describes our preliminary findings in comparing bone marrow fat fraction measurements in the presence of trabecular bone using water-fat imaging and single-voxel MRS. A good agreement was found between the two techniques after accounting for the effect of short T2* species.