Abstract #0194

Effect of Risk-Reducing Salpingo-Oophorectomy on Breast MRI Fibroglandular Tissue and Background Parenchymal Enhancement in BRCA1/2 Mutation Carriers: A Quantitative Assessment

Shandong Wu¹, Susan M. Domchek², Michael J. DeLeo, III³, Emily F. Conant³, Susan P. Weinstein³, Despina Kontos¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States; ²Medicine, University of Pennsylvania, Philadelphia, PA, United States; ³Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States

The purpose of this study is to perform an accurate and robust quantitative assessment to measure the effect of risk-reducing salpingo-oophorectomy (RRSO) on breast MRI fibroglandular tissue volume (FGT) and background parenchymal enhancement (BPE) in BRCA1/2 mutation carriers. The study was conducted using a fully automated breast MRI image segmentation method for quantitative FGT and BPE estimation. Our results show that quantitative rates of BPE-related measures are different before and after RRSO, while FGT-related measures are not. The BPE-related measures could potentially be used as imaging biomarkers to assess response to RRSO as a risk reduction intervention.