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Abstract #0195

Parenchymal Enhancement in the Contralateral Normal Breast of Patients Undergoing Neoadjuvant Chemotherapy Measured by DCE-MRI

Jeon-Hor Chen1, 2, Hon J. Yu1, Christine Hsu1, Muqing Lin1, Rita S. Mehta3, Min-Ying Su1

1Center for Functional Onco-Imaging,Department of Radiological Sciences, University of California Irvine, Irvine, CA, United States; 2Department of Radiology, , E-Da Hospital and I-Shou University, Kaohsiung, Taiwan; 3Department of Medicine, University of California Irvine, Irvine, CA, United States

In this study we measured the background tissue enhancement from the segmented fibroglandular tissue. We found a weak correlation between the percent density and the BPE, suggesting that although they were associated but not highly correlated. Women of younger age tended to have higher BPE than older women. Also, younger women were more likely to show decreased BPE after chemotherapy. The effect of BPE reduction in younger women was most likely due to the ovarian ablation induced by chemotherapeutic agents, thus it may be used as a risk predictor for development of contralateral breast cancer.