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Abstract #0207

Noninvasive Multi-Echo Vessel-Encoded Arterial Spin Labeling Reactivity for More Comprehensive Quantification of Hemodynamic Compensation: Development and Clinical Implementation in 50 Patients with Cerebrovascular Disease

Manus J. Donahue1, Paul Clemmons1, Ricardo Andal1, Robert Singer1, Diane Brown1, Morgan Anderson1, Dan Claassen1, John Connors1, Lisa Hermann1, Lori Jordan1, Howard Kirshner1, J. Mocco1, Ryan Moore1, Anne O'Duffy1, Derek Riebau1, Allen Sills1, Megan Strother1

1Vanderbilt University, Nashville, TN, United States

The purpose of this work is to develop and clinically implement a noninvasive MRI protocol for quantifying the relationship between key hemodynamic compensation mechanisms including cerebrovascular reactivity (CVR), baseline cerebral blood flow (CBF), CBF reactivity, and CBF territory dynamics in patients with cerebrovascular disease. This approach was implemented in 50 patients and results illuminated impairment not clear from structural imaging.