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Abstract #0208

Cerebral Perfusion and Vascular Reactivity in Insulin Resistance and Obesity

Henry Rusinek1, Jenny Ha2, Po Lai Yau2, Aziz Tirsi2, Wai Hon Tsui2, Antonio Convit2

1Radiology, NYU School of Medicine, New York, United States; 2Psychiatry, NYU School of Medicine, New York, United States

The obesity epidemic is responsible for the increasing prevalence of Type 2 diabetes (DB). Using a high-resolution ASL we present evidence that brain perfusion and vascular reactivity are affected in the early stage of DB. Insulin resistant (IR) subjects had significantly lower (p=0.008) resting gray matter flow (60.04.5) compared to healthy controls (63.66.4), with a trend for hypoperfusion in DB. There was a significant detrimental effect of obesity on vascular reactivity. Our findings suggest that cerebral blood flow and vascular reactivity changes resulting from obesity and insulin resistance are reversible.