Evaluation of a Multiparamteric QBOLD Approach in Acute Stroke Patients

Julien Bouvier¹, ², Olivier Detante¹, Irne Troprs³, Sylvie Grand¹, ⁴, David Chechin⁵, Jean-Franois Le Bas, ³⁴, Alexandre Krainik¹, ⁴, Emmanuel Luc Barbier¹

In stroke, Perfusion Weigthed Imaging (PWI) allows the identification of hypoperfused tissues. MRI characterization of the ischemic penumbra, defined by the diffusion-perfusion mismatch, can delineate penumbral and irreversibly infarcted fields with a similar degree of reliability to the gold standard, positron-emission tomography (PET). The presence of a diffusion-perfusion mismatch could justify thrombolysis therapy beyond 3h. The assessment of the penumbra using MRI remains controversial, however. The aim of this study is to evaluate how tissular oxygen saturation (StO2), assessed with a multiparametric qBOLD approach, fits between diffusion and perfusion acute stroke patients.