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Abstract #0210

Brain Connectivity and CBF Canges Fllowing Motor Training by MI-BCI Combined with TDCS in Stroke Patients

Xin Hong1, Yan Zhi Ong2, Irvin Teh3, Fatima Ali Nasrallah1, Zhong Kang Lu4, Wei Peng Teo5, Cuntai Guan4, Kai Keng Ang4, Kok Soon Phua4, Ling Zhao5, Effie Chew5, Kai-Hsiang Chuang1

1Singapore Bioimaging Consortium, Singapore, Singapore; 2Department of Biological Sciences, National University of Singapore, Singapore, Singapore; 3A*STAR-NUS Clinical Imaging Research Centre, Singapore, Singapore; 4Institute for Infocomm Research, Singapore, Singapore; 5The Division of Neurology and Rehabilitation Medicine, National University Hospital System, Singapore, Singapore

Perfusion and diffusion MRI were used to understand the plasticity in gray and white matters after motor training in stroke patients with impaired upper extremity. Robot-assisted motor imagery and brain-computer interface (MI-BCI) combined with or without transcranial direct current stimulation (tDCS) were conducted. Brain CBF change and FA changes along motor related fiber tracts are found after 2 weeks of training and correlate with clinical improvement. tDCS did not show significant effects on motor recovery. These findings will be helpful in understanding the role of neuroplasticity in motor recovery, and in the development of effective therapeutic approach for stroke rehabilitation.