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Abstract #0227

Apparent Diffusion Coefficient Decrease During Thermal Ablation of the Prostate as an Early Indicator for Loss of Tissue Viability.

Juan C. Plata1, Andrew B. Holbrook1, Michael Marx1, Vasant Salgaonkar2, Peter Jones2, Chris J. Diederich2, Aurea Pascal-Tenorio3, Donna Bouley3, Graham Sommer4, Kim R. Butts Pauly5

1Radiology, Stanford, Stanford, CA, United States; 2Radiaiton Oncology, University of California San Francisco, San Francisco, CA, United States; 3Comparative Medicine, Stanford, Stanford, CA, United States; 4Clinical Radiology, Stanford, Stanford, CA, United States; 5Radiology, Stanford University, Stanford, CA, United States

Diffusion weighted MRI (DWI) has demonstrated a 36% reduction in apparent diffusion coefficient (ADC) following HIU induced tissue damage of the prostate. We have previously used interleaved temperature and ADC measurements to extract tissue viability information from ADC measurements that are also dependent on temperature. Our purpose is to demonstrate that the decrease/plateau of ADC during sonication of the prostate was indicative of a transition from viable to non-viable tissue. We monitored treatments on healthy tissue as well as previously damaged tissue to assess whether our proposed marker of tissue viability is reliable and agrees with histology.