Abstract #0228

Selective Brain Cooling in Sheep by Intra-Ventricular Catheters: A 7T BIRDS Study

Daniel Coman¹, Yuegao Huang¹, John W. Simmons², James A. Goodrich³, Brain McHugh⁴, John A. Elefteriades⁵, Douglas L. Rothman¹,⁶, Fahmeed Hyder¹,⁶

¹Diagnostic Radiology, Yale University, New Haven, CT, United States; ²CoolSpine LLC, Woodbury, CT, United States; ³Comparative Medicine, Yale University, New Haven, CT, United States; ⁴Neurosurgery, Yale University, New Haven, CT, United States; ⁵Cardiothoracic Surgery, Yale University, New Haven, CT, United States; ⁶Biomedical Engineering, Yale University, New Haven, CT, United States

Selective brain cooling to induce hypothermia is a potentially important clinical tool for neuroprotection against cerebral ischemia and mitigates brain injury caused by brain trauma, cardiac arrest or stroke. Towards this goal we developed a ventricular cooling device for selectively inducing brain hypothermia. However, translation to humans requires understanding of local cooling efficiency, which can be obtained by temperature mapping. Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) was used to obtain the time dependence of absolute temperature distribution during cooling. Selective cooling of each hemisphere was achieved within 10 minutes and fast recovery to physiological temperature was also observed.